Process of making 4-imino-2-6-dioxypyrimidin.



'dissolvcd,

UNITED STATES PATENT OFFICE.

MAY CONRAD, OF ASCHAFFENBURG, AND \VALTER BECKH, OF UARM- STA DT;GERMANY.

Specification of Letters Patenli.

PROCESS OF MAKING 4-iMiN0-2-6-DIQXYPYRIMIDIN.

Patented Feb. 6, 1906.

application filed November 3,1904. Serial No. 231,287.

To all whom it my concern.-

Bc it known that wc, MAX (burial), professor of chemistry and doctor ofphiloso )hy, rcsidingat Aschall'cnhurg, and W ALTER 31mins, doctor ofphilosophy, rcsiding at Darmstadl, Germany, subjects of the GermanEmpcror, have invcnfcd certain now and useful linirovements in thoMamdacturc of Pyriinidin lkrivativcs, of which thc following is aspccification.

This invention has for its object the production of4-imino-Z.fi-dioxypyrimidin; and it consists in a process of condensingcyaniu-ctic-acid esters with urca in the presence of condensing agents,such as tho alkali alcoholates, thc alkali metals lhcmsclvcs, or theirainids.

The following equation may serve to illustratc the principal r'cactionwhich takcs placc in the ahovc-chnraclcrizcd condensation:

R000 Nlh (KL-k ln cnsco cm (30+ son.

l l or: Not, c so with twenty times thc quantity of alcohol in whichforty-six parts of sodium lmvo hccn Aftcraddition of fifty-eight partsof urca the mixture is boiled scvcral hours in connection with a rcllux'condcnscr. The product of reaction is then ncubralizcd, the: alcohol isdistillcd oil", the residue is taken up soa -h with watcr, and the4-imino-lfi-dioxypyriinidin is set free by acetic acid.

Exam )lO Twenty arts of dry urea arc ir'ltimacclymixcd with t w likcquantity of sodium amid and twenty parts of xylol arc poui-cd over it.Then with proper cx'tcrnal rcl'rigcration 17.5 parts of cyanacctioacidnwlhylcstcr are caused to flow upon this. After the principal reactionis over the prodnet of reaction is heated several hours to about 100 to120 cent-igradc. The vesicular dry melt is then takcn up in watcr withcareful avoidance of loo grcat heating. After the xylol is rcinovcd in asuilalilc manncr thc 4 iniino 3.6 -'dioxypyrimidin is prci-ipitatcd outof the solution of its sodium salt by tho addition of acclic acid or inanothcr suitahlc way.

The prorcss procccds in an analogous manncr for Lhc production oflimino-lli-dioxypyrimidin by condcnsing urca with other cyanacctic-acidStcrs in thc presence of alkali condcnsing agents.

llaving now described our invention and in what manncr the sonic is tobcpcrl'ormcd, what we claim as now, and dcsirc to secure by lmttcrslnlcnt is 1. 'lhc proccss of producing 4-imino-2.6- dioxyp ,'riniidin,which process consists in condcnsing urca and cyanacctic-iu'id cstcr inthe prcscocc ol an alkali condensing agcnt,

' substantially as dcscribcd.

l. The process of producing 4irnino2.6- dioxypyrimidin, which proccssconsists in condcnsing urea and cyanurctic-naill othycstcr in thoprcscncc of an alkali i'ondcnsing agcnt, suhstnnlially as dcscrilicd.

MAX CONRAD. WAlfllCll Bllllillj Witncsscs:

()rro Worms, WALTER. Ilousmm

